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Influence of ethanol and dexamethasone on blood‐brain barrier dysfunction to albumin
Author(s) -
ROSENGREN LARS E.,
PERSSON LENNART I.
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02918.x
Subject(s) - dexamethasone , extravasation , albumin , ethanol , blood–brain barrier , serum albumin , medicine , bovine serum albumin , endocrinology , chemistry , anesthesia , pharmacology , pathology , central nervous system , biochemistry
Stab‐wounded ethanol‐intoxicated and non‐intoxicated rats were studied with respect to the effect of postoperative dexamethasone treatment on blood‐brain barrier dysfunction to bovine albumin. In ethanol‐intoxicated rats, fluorescence microscopy revealed an increased area of extravasation of fluorescent tracer, compared to non‐intoxicated ones. No significant effect of dexamethasone treatment was observed in non‐intoxicated rats. In ethanol‐intoxicated rats, dexamethasone treatment resulted in a decreased area of extravasation. Quantitative immuno‐electrophoretic measurements of exogeneous bovine albumin confirmed a significant decrease of blood‐brain barrier dysfunction to albumin after dexamethasone treatment in ethanol‐intoxicated rats, while no significant effect was observed in non‐intoxicated ones.