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Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy
Author(s) -
BÄCKSTRÖM TORBJÖRN,
JORPES PER
Publication year - 1979
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1979.tb02912.x
Subject(s) - carbamazepine , phenobarbital , phenytoin , epilepsy , endocrinology , medicine , anticonvulsant , menstrual cycle , hormone , dose , psychiatry
Six menstrual cycles and three 1‐month periods were studied in seven patients with epilepsy. The patients all had had anti‐epileptic treatment for a long time. In each case, the dosages had been costant for at least 1 month prior to the start of the investigation. Blood samples were taken every second day. Phenytoin, phenobarbital, carbamazepine, estradiol and pregesterone were analyzed. The serum levels of the anti‐epileptic drugs were correlated to the plasma hormone concentrations. No correlations were obtained between the plasma hormone concentrations and the serum levels of the anti‐epileptic drugs. There is, therefore, no evidence that the relationship between the seizure frequency and plasma hormone concentrations, shown in a previous study ( Bäckström 1976)) was related to a change in serum levels of the anti‐epileptic drugs.