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Reversibility of the blood‐brain barrier dysfunction induced by acute hypertension
Author(s) -
Johansson Barbro B.,
Linder L.E.
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb04508.x
Subject(s) - evans blue , extravasation , blood–brain barrier , angiotensin ii , medicine , albumin , renin–angiotensin system , endocrinology , anesthesia , cardiology , blood pressure , pathology , central nervous system
An acute hypertensive episode of short duration (<3 mm) induced by i.v. injection of angiotensin in rats resulted in a blood‐brain barrier dysfunction that was rapidly reversible. Thus, no macroscopic extravasation was seen when Evans blue was given 10 or 20 min after angiotensin. A faint fluorescence (Evans blue‐albumin) was seen in the walls of some intracerebral arterioles in a few rats given the tracer 10 min after angiotensin.