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Progressive rubella virus panencephalitis: Synthesis of oligoclonal virus‐specific IgG antibodies and homogeneous free light chains in the central nervous system *
Author(s) -
Vandvik Bodvar,
Weil Marvin L.,
Grandien Monica,
Norrby Erling
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb04497.x
Subject(s) - subacute sclerosing panencephalitis , rubella virus , rubella , antibody , virology , cerebrospinal fluid , virus , immunology , immunoglobulin light chain , immunoglobulin g , medicine , slow virus , measles virus , viral disease , pathology , measles , vaccination
The occurrence of oligoclonal IgG and homogeneous free lambda light chains in the cerebrospinal fluid (CSF) of a patient with progressive rubella virus panencephalitis is reported. Fractions of oligoclonal IgG corresponding to those of the CSF occurred also in the serum. Evidence is presented that the oligoclonal IgG of serum and CSF represent rubella virus‐specific antibodies. Different populations of oligoclonal IgG appear to be associated with antibody specificities to different antigenic components of the virus.