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Clonidine in the prophylaxis of migraine
Author(s) -
Boisen Erik,
Deth Sven,
Huubbe Per,
Jansen Jette,
Klee Axel,
Leunbach Gustav
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02889.x
Subject(s) - clonidine , placebo , medicine , migraine , anesthesia , crossover study , ingestion , neurology , double blind , psychiatry , alternative medicine , pathology
The prophylactic effect of clonidine in a dosage of 0.05 mg twice daily was investigated in 49 patients using a double‐blind, crossover trial carried out in four Departments of Neurology. Seventy‐one patients were originally included but 22 patients withdrew, two of them due to side effects, the remainder because of inability to keep the requisite diary, lack of drug compliance or refusal to attend the checkups. Approximately equal numbers withdrew during the clonidine and placebo periods. There was no statistically significant difference between the number of migraine attacks or between the number of severe attacks (8 hours’duration or more) during the placebo and clonidine periods. This also applied to the patients with foodstuff‐provoked migraine attacks. Sixty‐three patients carried through a double‐blind, crossover trial with capsules containing either 125 mg tyramine or placebo. There was no significant difference between the number of patients who developed attacks after the ingestion of placebo and the number who did so after the ingestion of tyramine. The same is true of the group with foodstuffprovoked migraine. As a rule side effects were few and mild. This study has not confirmed that clonidine has any pharmacological effect in prophylaxis of migraine.