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Evaluation of the endocrine functions in dystrophia myotonica
Author(s) -
Henriksen Olaf A.,
Sundsfjord Johan A.,
NybergHansen Rolf
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02877.x
Subject(s) - prolactin , endocrine system , endocrinology , medicine , basal (medicine) , thyroid function , subclinical infection , hyperinsulinemia , hormone , physiology , diabetes mellitus , insulin resistance
Investigation of several endocrine functions was performed in seven patients with dystrophia myotonica (DM). All patients had hyperinsulinemia. Whereas the four female patients had normal pituitary‐gonadal function, all three male patients presented evidence of a primary gonadal failure. Thyroid function was normal in all patients. Four patients displayed abnormal diurnal variations of cortisol secretion. Basal prolactin levels were elevated in three patients, one of whom also had consistently elevated levels of growth hormone. The investigation adds some new evidence of neuroendocrine dysfunction at the hypothalamic level in DM.