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Computerized tomography in hereditary ataxias
Author(s) -
Pedersen Lene,
Gyldensted Carsten
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02864.x
Subject(s) - medicine , hereditary spastic paraplegia , ataxia , atrophy , paraplegia , lesion , spastic , degenerative disease , central nervous system disease , pathology , radiology , disease , surgery , spinal cord , cerebral palsy , physical medicine and rehabilitation , biochemistry , chemistry , psychiatry , gene , phenotype
Thirty‐nine patients with hereditary ataxia (HA), hereditary spastic paraplegia or Charcot‐Marie‐Tooth disease were investigated with computerized cranial tomography (CT). Infratentorial as well as supratentorial atrophies were registrated and scored. These were compared with the patient's neurological symptoms, which were related to the lesion in the central nervous system, and scored. There was correlation between the distribution of brainstem/cerebellar symptoms and the distribution and degree of infratentorial atrophy. HA cases with cerebral cortical atrophy had significantly higher dementia scores than those without wide sulci. Intravenous injection with contrast medium was of no diagnostic aid, as no focal changes were found. It is concluded that CT is an aid in the diagnosis of hereditary ataxias and hereditary spastic paraplegia.