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E rosette‐forming lymphocytes in multiple sclerosis patients. Basic protein stimulation of rosette‐forming cells
Author(s) -
Offner H.,
Konat G.,
Raun N. E.,
Clausen J.
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02841.x
Subject(s) - multiple sclerosis , stimulation , myelin basic protein , rosette (schizont appearance) , t cell , rosette formation , immunology , medicine , myelin , immune system , central nervous system , antibody
“Total” and “active” T cells were enumerated using sheep red blood cell (SRBC) rosetting technique. the percentages of “total” and “active” T lymphocytes were not significantly different in multiple sclerosis patients as compared to other neurological disorders and/or healthy controls. However, the number of “avid” T cells binding more than three SRBC was significantly increased in MS patients. Active E rosette test has shown hypersensitization to myelin basic protein in 50 % MS patients and 31 % OND patients. All healthy controls studied, except one had negative response.