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Effect of dexamethasone on protein extravasation in the brain in acute hypertension induced by amphetamine
Author(s) -
Johansson Barbro B.
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02835.x
Subject(s) - extravasation , evans blue , dexamethasone , amphetamine , blood–brain barrier , medicine , blood pressure , anesthesia , albumin , vasodilation , vascular permeability , endocrinology , pharmacology , central nervous system , pathology , dopamine
Amphetamine produces protein leakage in the brain when given to rats under nitrous oxide anesthesia. the blood‐brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg. kg ‐1 , diminished the amphetamine‐induced extravasation of Evans blue albumin and 125 IHSA in the rats' brain. Possible explanations to the effect of dexamethasone on cerebrovascular permeability are discussed.