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Studies on the influence of monoamines on the cerebrovascular response to arterial hypoxia
Author(s) -
EkströmJodal Barbro,
Elfverson Jörgen,
Essen Claes
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02833.x
Subject(s) - blockade , hypoxia (environmental) , pimozide , dopamine , dopamine receptor , stimulation , haloperidol , medicine , endocrinology , receptor , pharmacology , chemistry , oxygen , organic chemistry
The cerebrovascular response to arterial hypoxia was studied during blockade of the vascular dopamine receptors and during alpha‐adrenergic receptor stimulation and blockade in anaesthetized dogs. Dopamine‐receptor blockade with pimozide or haloperidol invariably decreased the degree of hypoxic vasodilatation in the brain pointing to a functional role of dopamine in this situation. Alpha‐receptor blockade did not change the response, while stimulation of these receptors decreased the dilatory response even in deep arterial hypoxia.