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LACK OF EFFECT OF CLONAZEPAM, ON SERUM LEVELS OF DIPHENYLHYDANTOIN, PHENOBARBITAL AND CARBAMAZEPINE
Author(s) -
Johannessen Svein I.,
Strandjord Roald E.,
MuntheKaas Anders W.
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb07629.x
Subject(s) - clonazepam , carbamazepine , phenobarbital , anticonvulsant , pharmacology , phenytoin , epilepsy , serum concentration , medicine , anesthesia , psychiatry
The influence of clonazepam on steady‐state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs. Clonazepam was given in slowly increasing doses for 2 weeks until a maximum dose of 66 mg per day was reached; thereafter the dose was kept constant. The serum levels of diphenylhydantoin, phenobarbital and carbamazepine were determined once a week for at least 6 weeks. During clonazepam medication in ordinary doses the serum levels of the drugs in question were unaltered. Thus, it is unlikely that the antiepileptic effect of clonazepam in these patients even partly may be due to increased serum levels of these other drugs mentioned.