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PLASMA PROTEIN BINDING OF PHENYTOIN AFTER CHOLECYSTECTOMY AND NEUROSURGICAL OPERATIONS
Author(s) -
Elfström Johan
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb07625.x
Subject(s) - phenytoin , cholecystectomy , free fraction , medicine , plasma protein binding , blood proteins , plasma levels , anesthesia , chemistry , pharmacology , epilepsy , surgery , psychiatry
The purpose of the present study was to investigate whether changes in the protein binding of phenytoin occur postoperatively. Fourteen patients were studied after cholecystectomy and six patients after operations for intracranial aneurysm or meningeoma. It was found that the fraction of phenytoin not bound to plasma proteins rose significantly after operation. The total concentration, on the other hand, decreased, so the concentration of free phenytoin did not change much. Possible explanations to the changes observed are discussed, as well as the clinical usefulness of determination of the protein binding of phenytoin.