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LYSOZYME ACTIVITY IN CEREBROSPINAL FLUID
Author(s) -
Hansen Niels Ebbe,
Karle Hans,
Jensen Anette,
Rock Elisabeth
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb05660.x
Subject(s) - lysozyme , cerebrospinal fluid , meningitis , multiple sclerosis , medicine , csf albumin , pathology , encephalitis , serous fluid , immunology , blood–brain barrier , albumin , central nervous system , biology , virus , biochemistry , psychiatry
Lysozyme activity was measured in cerebrospinal fluid (CSF) from 114 patients with inflammatory (bacterial and serous meningitis, poly‐radiculitis, encephalitis) and non‐inflammatory (multiple sclerosis, CNS tumors, cerebral vascular diseases) CNS diseases. Highly elevated values were found consistently in patients with bacterial meningitis. Elevated values were found also in patients with encephalitis, poly‐radiculitis, multiple sclerosis and CNS tumors, but a considerable overlapping between these groups and normal controls precludes the use of CSF lysozyme measurements as a diagnostic aid in the latter disease groups. Simultaneous measurements of lysozyme, albumin and IgG in CSF and serum suggested that the mechanism for increased CSF lysozyme values in bacterial meningitis is mainly a breakdown of the blood/brain barrier, whereas the increased CSF lysozyme values in the remaining groups of patients are more likely caused by production of lysozyme by cells within the meninges (neutrophilic granulocytes, monocytes?).