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ULTRASTRUCTURE OF MUSCLE BIOPSIES IN RECENT, SHORT‐TERM AND LONG‐TERM JUVENILE DIABETES
Author(s) -
ReskeNielsen Edith,
Harmsen Aage,
Vorre Peter
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb05654.x
Subject(s) - juvenile , diabetes mellitus , ultrastructure , pinocytosis , atrophy , pathology , anatomy , basement membrane , electron microscope , medicine , biology , endocrinology , genetics , endocytosis , receptor , physics , optics
ABSTRACT Muscle biopsies from juvenile diabetics were studied by electron microscopy and the results correlated to earlier published light microscopical abnormalities of the same biopsies. A total of 32 striated muscle biopsies from 29 juvenile recent, short‐term and long‐term diabetes were examined. The ages ranged from 16 to 43 years with a diabetes duration from 1 week to 32 years. The material was compared with biopsies from healthy persons of the same ages. The electron microscopy revealed degenerative changes of the striated muscle fibres which signify a neurogenic atrophy. No myopathic alterations were found. The capillaries in both the recent and long‐term diabetics showed an extremely pronounced pinocytosis indicating an increased metabolic activity. In the long‐term group the intramuscular capillaries both from upper and lower extremities displayed a definitely thickened basement membrane. In the recent and short‐term group the capillary wall alterations were debatable. The motor end plate in the recent diabetics revealed minimal alterations. Contrary to this the long‐term group showed severe alterations with occasional disappearance of the nerve fibres.