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THE CEREBROVASCULAR PERMEABILITY TO PROTEIN AFTER BICUCULLINE AND AMPHETAMINE ADMINISTRATION IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Johansson Barbro B.
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb01447.x
Subject(s) - bicuculline , amphetamine , blood pressure , vasodilation , medicine , nifedipine , lumen (anatomy) , hemodynamics , muscle hypertrophy , endocrinology , anesthesia , dopamine , calcium , gabaa receptor , receptor
Hemodynamic and morphometric studies on spontaneously hypertensive rats (SHR) have suggested that the lumen to wall ratio of the resistance vessels is decreased due to hypertrophy of the media. As the tension in the vessel wall increases with the pressure and the radius and decreases with the vessel wall thickness, such vessels would be expected to withstand higher pressure than vessels of normotensive rats (NR) unless local wall defects were present. Bicuculline‐induced epileptic activity and amphetamine intoxication, two conditions with cerebral vasodilatation and high blood pressure, give rise to extensive protein leakage in the brain of NR. Consistent with the hypothesis presented above, less protein leakage occurred in brains of SHR than in brains of NR after amphetamine and bicuculline administration.