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MOTOR NEURON DISEASE
Author(s) -
Kristensen O.,
Melgaard B.
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb01437.x
Subject(s) - motor neuron , disease , neuroscience , amyotrophic lateral sclerosis , medicine , physical medicine and rehabilitation , psychology , pathology
In order to evaluate the prognosis and possible prognostic factors associated with a benign course, 118 cases of motor neuron disease diagnosed 1948–1975 were followed up. Survival curves, based on the actuarial method showed a survival rate of 18.7 per cent (95 per cent confidence limits: 11.4–26.0) and 7.6 per cent (95 per cent confidence limits: 2.7–12.5) after 5 and 10 years respectively. Comparing the survival curves of males/females, cases with bulbar/spinal‐and upper/lower extremity onset, cases with/without upper motor neuron signs, only bulbar onset was associated with a significantly poorer prognosis. However, cases with bulbar onset had a significantly higher mean age of onset. Based on cases from Funen county with a 1970‐population of 432,699 we found an average annual incidence rate, mortality rate and period prevalence rate of 0.85, 0.86 and 2.5 per 100,000 respectively. Comparing the incidence per 5‐year period through 1948–1972, no significant deviations indicating a changing environmental factor were found.