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TREATMENT OF HUNTINGTON'S CHOREA WITH BROMOCRIPTINE
Author(s) -
Frattola Lodovico,
Albizzati Maria Grazia,
Spano Pier Franco,
Trabucchi Marco
Publication year - 1977
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1977.tb01407.x
Subject(s) - bromocriptine , chorea , dopaminergic , medicine , agonist , crossover study , antagonist , dopamine agonist , double blind , psychology , disease , receptor , dopamine , placebo , hormone , pathology , alternative medicine , prolactin
The authors tested the effects of 2‐Br‐ergocriptine (bromocriptine, CB‐154), a drug which exerts a mixed agonist‐antagonist activity on the dopaminergic receptors, in 12 patients with Huntinton Chorea in a double‐blind crossover trial. This treatment significantly reduced the abnormal involuntary movements and the disease severity in most of the patients. Subjects who were slightly disabled showed a better response than the ones with more severe degrees of disability.