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CLONUS DEPRESSION BY PROPRANOLOL
Author(s) -
Mai Jesper,
Pedersen Ejner
Publication year - 1976
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1976.tb04358.x
Subject(s) - clonus , propranolol , tonic (physiology) , reflex , spastic , stretch reflex , medicine , anesthesia , spinal cord , inhibitory postsynaptic potential , physical medicine and rehabilitation , neuroscience , psychology , epilepsy , cerebral palsy
Propranolol administered i.v. to spastic patients was found to be capable of depressing clonus. the drug exerts its action on the spinal the cord but does not influence dynamic spindle activity or alpha‐motomneurone activity as tested by the T (Achilles tendon) and H reflexes. It may disinhibit the tonic stretch reflex. Thus, clonus is dependent not only on dynamic spindle activity but also on another, probably inhibitory, mechanism.