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LOCALIZATION of PHENOBARBITAL IN MOUSE CENTRAL NERVOUS SYSTEM BY IMMUNOFLUORESCENCE
Author(s) -
Pertschuk Louis P.,
Ford Donald H.,
Rainford Evelyn A.,
Brigati David J.
Publication year - 1976
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1976.tb04352.x
Subject(s) - phenobarbital , central nervous system , cerebellum , immunofluorescence , spinal cord , nervous system , limbic system , medicine , neuroscience , pathology , anatomy , biology , immunology , antibody
Utilizing antibarbiturate serum in an indirect immunofluorescence system, phenobarbital has been detected in the central nervous system of mice given an overdose of drugs. Localization was primarily within neurons of the limbic system, caudate nucleus, cerebellum, cervical spinal cord and trigeminal ganglion. the technic may be of value in acquiring additional information about the barbiturates as well as being of value to the forensic pathologist.