Premium
CONCENTRATIONS OF MONOAMINE METABOLITES IN HUMAN LUMBAR AND CISTERNAL CEREBROSPINAL FLUID
Author(s) -
Johansson Barbro,
Roos BjörnErik
Publication year - 1975
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1975.tb05767.x
Subject(s) - cerebrospinal fluid , lumbar , monoamine neurotransmitter , lumbar puncture , anesthesia , chemistry , medicine , serotonin , anatomy , receptor
5HIAA and HVA were determined in successive samples of CSF withdrawn at the lumbar and cisternal levels in connection with gas myelographic examinations in 16 patients. The mean of 5‐HIAA in the first cisternal samples were 83 ng/ml (n = 8) and of HVA 143 ng/ml (n = 7). A sharp increase in the concentration of both metabolites, but particularly of HVA, was seen in successive lumbar samples. The ratio of cisternal/lumbar 5‐HIAA was 3/1, and of HVA 10/1 in one patient in whom lumbar and cisternal CSF were obtained with 2 weeks’interval. The concentrations of monoamine metabolites in CSF obtained at lumbar puncture are thus highly dependent on the amount of fluid withdrawn. This fact should be taken into consideration when different materials are compared.