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DEMONSTRATION OF OLIGOCLONAL IMMUNOGLOBULIN G IN GUILLAIN‐BARRÉ SYNDROME
Author(s) -
Link Hans
Publication year - 1975
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1975.tb05765.x
Subject(s) - guillain barre syndrome , immunoglobulin g , antibody , medicine , immunology
Elevated concentrations in CSF of the immunoglobulins G, A, and M, when expressed as a percentage of the total protein concentration of CSF, were demonstrated during the initial phase of the course of the disease in a patient with Guillain‐Barré syndrome (GBS). A slight elevation of the relative concentrations of IgG and IgM in CSF were also registered later in the course of the disease, at the time when the patient's neurological symptoms were in regression. Multiple discrete IgG bands were demonstrated by agarose electrophoresis in serum and in CSF during the first 12 weeks after onset of the neurological symptoms, and also after week 5 and still during week 12 after onset. The finding of transient oligoclonal IgG in a patient with GBS may suggest stimulation with e.g. viral antigen.