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A DOUBLE BLIND STUDY OF CARBAMAZEPINE AND DIPHENYLHYDANTOIN IN TEMPORAL LOBE EPILEPSY
Author(s) -
Simonsen Niels,
Olsen Poul Zander,
Kühl Viggo,
Lund Mogens,
Wendelboe Jørgen
Publication year - 1975
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1975.tb01386.x
Subject(s) - carbamazepine , epilepsy , temporal lobe , complex partial seizures , medicine , anesthesia , anticonvulsant , phenytoin , double blind study , therapeutic effect , pharmacology , double blind , psychiatry , pathology , alternative medicine , placebo
In a double blind study no difference was found between carbamazepine and diphenylhydantoin with regard to efficacy in preventing temporal lobe seizures, i.e. partial seizures with complex symptomatology, when the drugs were given without other medication for periods of 16 weeks, and when the serum concentrations were within selected therapeutic levels corresponding to usual therapeutic dosage. Some patients, however, had considerably fewer seizures on carbamazepine, some on diphenylhydantoin. It therefore seems advisable to try both drugs separately, before using a combined medication.