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A DOUBLE‐BLIND TRIAL WITH BACLOFEN (LIORESAL®) AND DIAZEPAM IN SPASTICITY DUE TO MULTIPLE SCLEROSIS
Author(s) -
From Arne,
Heltberg Anne
Publication year - 1975
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1975.tb01366.x
Subject(s) - spasticity , sedation , clonus , tolerability , medicine , anesthesia , diazepam , side effect (computer science) , baclofen , significant difference , epilepsy , adverse effect , psychiatry , agonist , receptor , computer science , programming language
In 17 in‐patients suffering from spasticity due to multiple sclerosis, the effect and tolerability of baclofen (Lioresal®) and diazepam were studied in a double‐blind, within patient trial with random allocation and flexible dose. The treatment periods were 4 weeks each. As to efficacy, the variables: spasticity, clonus, flexor spasms, gait and bladder function were evaluated clinically. No significant difference was found between the two drugs. As far as side‐effects are concerned, sedation was specifically inquired about. Apart from that, spontaneously reported side‐effects were recorded. Sedation was more often seen during treatment with diazepam, while the side‐effects during baclofen treatment were more varied. The total number and severity of side‐effects were equal in the two treatment groups. A preference for one of the two treatment periods was stated by the investigator before the code was broken. A significant difference ( P <0.001) in favour of Lioresal® was found. This is discussed in the light of the fact that no significant difference was found for the individual symptoms or side‐effects.