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THE CEREBRAL COPPER‐PROTEIN COMPLEXES IN HEPATO‐LENTICULAR DEGENERATION STUDIED BY MEANS OF ELECTRON‐SPIN‐RESONANCE TECHNIQUE
Author(s) -
Wender M.,
Adamczervska Z.,
Gruszczyńska U.,
Dezor A.
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02821.x
Subject(s) - electron paramagnetic resonance , copper , nuclear magnetic resonance , pathological , degeneration (medical) , chemistry , magnetic resonance imaging , spin (aerodynamics) , paramagnetism , pathology , crystallography , medicine , condensed matter physics , physics , radiology , thermodynamics , organic chemistry
The electron‐spin‐resonance spectra of cupric complexes existing in brains with hepato‐lenticular degeneration were analyzed and quantitatively evaluated with regard to unit mass and compared with those of control brains. Compared with control specimens, the brains with Wilson's disease showed an approximately five–fold increase in copper content; but there were no detectable differences in the paramagnetic characteristics of the cupric complexes between the control and pathological brains. The content and paramagnetic spectrum of the iron complexes were found to be unchanged in the brains with Wilson's disease.