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THE LOWERING EFFECT OF DEEP‐FROZEN STORAGE ON THE y‐GLOBULIN CONCENTRATION OF THE CEREBROSPINAL FLUID AFTER ENCEPHALOGRAPHY
Author(s) -
Iivanainen Matti,
Kostiainen Ella
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02811.x
Subject(s) - cerebrospinal fluid , chemistry , irritation , globulin , medicine , pathology , immunology
To assess the behaviour in deep‐frozen storage of the cerebrospinal fluid (CSF) γ‐globulin after gas encephalographic irritation, 40 CSF samples from 10 patients with various non‐demyelinating neurological disorders (Table 1) were analysed. The samples, taken immediately before and during gas encephalography (GEG), were examined by means of the cellulose acetate electrophoresis when fresh and after one year's deep‐frozen storage. The γ‐globulin in the samples taken before GEG remained unchanged, but in the samples with GEG irritation the γ‐globulin decreased statistically significantly during deep‐frozen storage (from 10.0±2.5 to 7.4±2.2 per cent; P < 0.05). We consider that the irritative effect of GEG causes an influx of small‐sized protein molecules into the CSF by changing the membrane permeability. As these proteins are known to become denatured and disappear during deep‐frozen storage, they could be responsible for the phenomena observed.