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BLOOD‐BRAIN BARRIER DYSFUNCTION IN ACUTE ARTERIAL HYPERTENSION INDUCED BY CLAMPING OF THE THORACIC AORTA
Author(s) -
Johansson Barbor,
Linder LarsErik
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02784.x
Subject(s) - extravasation , thoracic aorta , medicine , evans blue , blood–brain barrier , blood pressure , cardiology , aorta , vascular permeability , anesthesia , albumin , pathology , central nervous system
Acute experimental hypertension induced by clamping of the thoracic aorta resulted in blood‐brain barrier dysfunction as revealed by extravasation of Evans blue‐albumin in 10 out of 13 dogs. The tracer distribution was similar to that found in animals with metaraminol‐induced hypertension, which supports the hypothesis that the high intravascular pressure per se and not any toxic drug effect is the factor that brings about increased permeability to protein tracers.