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HISTOCHEMICAL DEMONSTRATION OF SYMPATHETIC ADRENERGIC DENERVATION IN HUMAN SKIN
Author(s) -
Norberg KarlAxel,
Normell Lars A.
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02778.x
Subject(s) - vasomotor , adrenergic , sympathetic denervation , denervation , medicine , sympathetic nervous system , sympathetic nerve , sympathectomy , sympathetic innervation , anatomy , pathology , blood pressure , receptor
A fluorescence histochemical method was applied to human skin biopsies for studying the extent of sympathetic adrenergic denervation after neurological lesions. Seven out of eight paraplegics had histochemically detectable adrenergic innervation in skin areas lacking sensibility and cutaneous vasomotor function. No adrenergic nerve terminals were found in skin biopsies from skin areas deprived of sensibility and vasomotor function in one paraplegic patient and two patients with perepheral nerve lesions. It is concluded that the histochemical method provides a means of differentiating between pre‐ and postganglionic lesions in the adrenergic sympathetic system supplying the skin.