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ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENINGITIS AND ENCEPHALITIS
Author(s) -
Bakke O. M.,
Guldberg H. C.,
Schreiner A.
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02768.x
Subject(s) - cerebrospinal fluid , homovanillic acid , monoamine neurotransmitter , meningitis , lumbar puncture , aseptic meningitis , medicine , encephalitis , anesthesia , gastroenterology , immunology , serotonin , surgery , virus , receptor
The concentrations of the acid monoamine metabolites homovanillic acid (HVA) and 5‐hydroxyindolcacetic acid (5‐HIAA) were measured by spectrophotofluorometric techniques in lumbar cerebrospinal fluid obtained from patients with meningitis and encephalitis. Very high concentrations of HVA were found in 4 patients with bacterial meningitis in the acute stage and a marked fall was observed after treatment. The levels found in 3 patients with aseptic meningitis and in 2 out of 4 patients with encephalitis were also above the control values. Interference with the active transport mechanism for acid monoamine metabolites from cerebrospinal fluid to blood may account for the high concentrations of HVA found in patients with meningitis. In a limited material investigated there was no obvious difference between the levels of 5‐HIAA found in cerebrospinal fluid obtained from meningitic patients as compared to controls.