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CELL‐FREE PROTEIN SYNTHESIS BY RAT BRAIN IN TRIETHYL TIN INTOXICATION
Author(s) -
Wender M.,
Zgorzalewicz B.,
Piecrowski A.
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb01349.x
Subject(s) - white matter , grey matter , amino acid , chemistry , myelin , proline , biochemistry , medicine , endocrinology , pharmacology , central nervous system , magnetic resonance imaging , radiology
An acute cerebral oedema was induced in rats by administration of triethyl tin at a dose of 4 mg per kg body weight. Studies involved tracing of L‐[ 14 C] leucine and L, [ 14 C] proline incorporation to the postmitochondrial fraction of the cerebral white and grey matter. Morphological studies disclosed spongious changes in the white matter (typical for TET intoxication). Biochemical studies demonstrated a pronounced reduction of labelled leucin incorporation, particularly in the white matter. A reduction of incorporation of the other amino acid studied (proline) was not so marked, although significant for the white matter. The results seem to indicate that a diminished protein biosynthesis is an essential although certainly not the only metabolic cause of the white matter lesion, particularly of the myelin, in TET intoxication.