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WIRKUNG VON CLONAZEPAM AUF DAS EEG VON KINDERN UND JUGENDLICHEN
Author(s) -
Rosenmayr F. W.,
Groh Ch.
Publication year - 1973
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1973.tb02294.x
Subject(s) - clonazepam , electroencephalography , hypsarrhythmia , anesthesia , exacerbation , medicine , spike and wave , psychology , psychiatry
The influence of clonazepam (Ro 5‐4023) on the EEG was studied in 80 patients. The EEG was recorded before, during and after intravenous administration. Beta activity occurred in practically all cases. In 26 children the record was normalized, and there was remarkable improvement in another 26 patients. One record showed exacerbation. In 27 cases the tracing was essentially unchanged. In 4 of these 27 cases the EEG was normal before administration of clonazepam. The distribution of the 76 abnormal EEG records was as follows: Group A: 24 with focal sharp waves and spikes. Group B: 6 with focal spikes and waves. Group C: 37 with generalized spike‐and‐wave discharges. Group D: 9 with hypsarrhythmia, generalized spikes, theta rhythms etc. Group C showed the best results. Normalization 18 (out of 26). Remarkable improvement 10 (out of 26). No change 9 (out of 23). In 9 children the effect was controlled. In 7 the improvement could be repeated, in 2 the effect was constantly insufficient. A wide range of dosage was given (0.03–0.3 mg/kg).