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KLINISCHE UND HIRNELEKTRISCHE PRÜFUNG VON CLONAZEPAM (Ro 5‐4023) UNTER BESONDERER BERÜCKSICHTIGUNG DES STATUS EPILEPTICUS
Author(s) -
Ketz E.,
Bernoulli C.,
Siegfried J.
Publication year - 1973
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1973.tb02284.x
Subject(s) - clonazepam , status epilepticus , electroencephalography , anesthesia , medicine , scalp , drug administration , petit mal , epilepsy , surgery , psychiatry
Clonazepam (Ro 5‐4023) was tested in 65 instances of clinical and electroencephalographic status epilepticus. In 37 cases a scalp EEG was obtained during injection of the drug, which was mostly by the i. v. route. In 6 cases the drug was injected in the course of Stereo‐EEG exploration. Especially by intravenous administration and even in very small doses the drug rapidly produced a clinical effect. Of the patients 83.3 per cent responded either at once or after a second injection (1–4 mg). Particularly patients with primary generalized or focal, secondary generalized seizures responded favourably to the treatment. Improvement of the scalp EEG correlated with clinical effectiveness. Stereo‐EEG showed abolition of both spontaneous and evoked seizure discharges in various brain structures or limitation of their spread from the depths to the isocortex, thus facilitating localization of the foci.