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EFFECT OF CLONAZEPAM (Ro 5‐4023) ON INTERICTAL EEG ABNORMALITIES
Author(s) -
Häkkinen Veikko
Publication year - 1973
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1973.tb02283.x
Subject(s) - clonazepam , hyperventilation , electroencephalography , spike and wave , anesthesia , ictal , audiology , psychology , medicine , neuroscience
An attempt was made to quantify changes in EEG abnormalities after an i.v. injection of clonazepam (Ro 5‐4023). The number of spikes and sharp‐waves per 30 sec and percentage of the total duration of generalized paroxysms (with/without spike‐ or sharp‐wave components) were calculated differentially. Epileptic patients with marked EEG abnormalities were selected for the study. The EEG tracings from which the calculation were made were recorded approx. 10 min before and after (the completion of) the injection of 1–2 mg clonazepam. In the 2 patients who continuously had spike‐and‐wave discharges only during hyperventilation (HV), the calculations were made exceptionally from 4‐min‐samples with 3 min of HV initially. Some marked differences are seen in the effects of clonazepam on the EEG abnormalities. The clinical consequences of these differences will be tested in a follow‐up study.