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SLOWLY ABSORBED L‐DOPA PREPARATION IN THE TREATMENT OF PARKINSONISM
Author(s) -
Laitinen Lauri V.
Publication year - 1973
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1973.tb01306.x
Subject(s) - parkinsonism , nausea , medicine , adverse effect , anesthesia , surgery , disease
A new, slowly absorbed L‐dopa preparation of sustained release‐type was used in an open study on 25 Parkinsonian patients. The 24‐hour serum concentration was found to be relatively even when three daily doses were used. The average dose was 3.5 g a day. Thirteen patients experienced adverse effects, of which nausea was the most common. Purdue pegboard and electronic measurement of motor reaction times showed that 80 per cent of the patients improved during the test period of 15 weeks. The new preparation was considered to be equal to, or slightly better than, the previous rapidly absorbed L‐dopa preparations. The present study confirmed our previous finding that thala‐motomized patients benefit from L‐dopa less than non‐surgical patients.