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THE PERMEABILITY OF THE BLOOD‐BRAIN BARRIER TO 51 Cr‐EDTA IN RABBITS WITH EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
Author(s) -
Amtorp Ole,
Sørensen Søren Claus
Publication year - 1973
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1973.tb01305.x
Subject(s) - encephalomyelitis , blood–brain barrier , cerebrospinal fluid , multiple sclerosis , medicine , central nervous system , immunology , subacute sclerosing panencephalitis , pathology , gamma globulin , globulin , measles , antibody , measles virus , vaccination
In multiple sclerosis and subacute sclerosing panencephalitis the concentrations of γ‐globulins in cerebrospinal fluid are increased. This might be due to a breakdown of the blood‐brain barrier or it might be the result of a synthesis of γ‐globulins within the central nervous system. In an attempt to distinguish between these two possibilities, we sought an animal model for the demyelinating diseases seen in humans. In experimental allergic encephalomyelitis the concentration of γ‐globulins in cerebrospinal fluid is also increased, and we therefore examined the permeability of the blood‐brain barrier in this disease. We compared the uptake of 51 Cr‐EDTA (MW = 359) in the brain in ten rabbits with experimental allergic encephalomyelitis with that in eight normal rabbits. We did not find any difference between the two groups, and we must therefore conclude that there is not a widespread increase in the permeability of the blood‐brain barrier in rabbits with clinically manifest experimental allergic encephalomyelitis. However, we cannot exclude that the permeability might be increased in discrete areas of the brain.