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COMPLEMENT‐FIXING ANTIBRAIN ANTIBODIES IN MULTIPLE SCLEROSIS A Preliminary Report
Author(s) -
Laurell AnnaBrita,
Link Hans
Publication year - 1972
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1972.tb07567.x
Subject(s) - multiple sclerosis , cerebrospinal fluid , antibody , medicine , antigen , complement (music) , immunology , immunization , pathology , biology , complementation , gene , phenotype , biochemistry
Complement fixing antibrain antibodies were found in cerebrospinal fluid (CSF) from 6 of 12 patients with multiple sclerosis (MS), but not in any of 17 CSF specimens from patients with other neurological disorders when tested with a crude MS brain preparation as antigen. Complement fixing antibrain antibodies in lower titres were also found in 5 of the 6 positive MS CSF specimens when tested with a control brain preparation as antigen. The findings indicate the occurrence in MS of an immunization against brain components.