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ELECTROENCEPHALOGRAPHIC AND HISTOPATHOLOGICAL CHANGES RESEMBLING JAKOBCREUTZFELDT DISEASE AFTER TRANSIENT CEREBRAL ISCHEMIA DUE TO CARDIAC ARREST
Author(s) -
Nilsson Bengt Yngve,
Olsson Yngve,
Sourander Patrick
Publication year - 1972
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1972.tb07563.x
Subject(s) - gliosis , pathology , medicine , ischemia , electroencephalography , basal ganglia , cerebral cortex , cerebral hypoxia , disease , central nervous system , cardiology , psychiatry
Electroencephalographic changes similar to those seen in the subacute stage of Jakob‐Creutzfeldt disease were observed in two comatose patients surviving 1 and 3 months respectively after a period of transient cerebral ischemia caused by cardiac arrest. Neuropathological examination revealed severe neuronal changes, status spongiosus and gliosis of cerebral and cerebellar cortex and of basal ganglia. The distribution and character of the lesions closely resembled those known to occur in subacute cases of Jakob‐Creutzfeldt disease. The rhythmical EEG changes characteristic of the subacute stage of Jakob‐Creutzfeldt disease diminish in the terminal stage of this disorder, and this type of activity has not been seen in more severe cases of ischemic brain injury. These EEG changes, therefore, may be related to the degree of the corresponding morphological brain lesions and not to their etiology.