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HORMONAL PROTECTION OF RATS BREATHING OXYGEN AT HIGH PRESSURE 1,2
Author(s) -
Troy Shuang S.,
Ford Donald H.
Publication year - 1972
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1972.tb07544.x
Subject(s) - adrenalectomy , hormone , endocrinology , medicine , oxygen , edema , anesthesia , chemistry , organic chemistry
Sex differences in susceptibility to high pressure oxygen (OHP)‐induced convulsions were observed in mature rats. Male rats convulsed significantly earlier than did females. After adrenalectomy, seizures disappeared in most females and some male rats. The number of adrenalectomized male rats which resisted OHP‐induced convulsions increased from 40 % to 91 % when they were treated with estradiol subcutaneously. Rats which do not convulse during the exposure to OHP eventually develop pulmonary edema and congestion and die. Strain variations in respect to susceptibility to oxygen poisoning and the contreversal nature of OHP and electroshock‐induced convulsions in response to steroid hormones are discussed.