Premium
ANTIEPILEPTIC DRUG CONCENTRATIONS IN PLASMA: Clinical Evaluation of 321 Estimations in 237 Unselected Patients
Author(s) -
GardnerThorpe C.,
Parsonage M. J.,
Smethurst P. F.,
Toothill C.
Publication year - 1972
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1972.tb07542.x
Subject(s) - drug , plasma concentration , plasma , plasma levels , pharmacology , antiepileptic drug , medicine , chromatography , chemistry , epilepsy , psychiatry , physics , quantum mechanics
Two chromatographic methods of estimating plasma concentrations of antiepileptic drugs, designed by the authors and described elsewhere, have been used to examine 321 samples of plasma. The methods have been shown to be simple and to fit satisfactorily into a busy laboratory programme. Results obtained with both methods have been found to agree with those of other workers who used a wide variety of techniques. Ranges of plasma concentrations of four commonly‐used drugs have been established. Plasma concentrations do not correlate well with drug doses in individual patients. Negligible plasma concentrations have been found in some patients. Possible metabolic interactions have been revealed.