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STUDIES OF THE MONOAMINE METABOLISM IN THE CENTRAL NERVOUS SYSTEM IN JAKOB‐CREUTZFELDT DISEASE
Author(s) -
Brun A.,
Gottfries C. G.,
Roos B. E.
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07515.x
Subject(s) - monoamine neurotransmitter , cerebrospinal fluid , probenecid , disease , central nervous system , medicine , dopamine , metabolism , etiology , creutzfeldt jakob syndrome , pathology , serotonin , prion protein , receptor
In a case with Jakob‐Creutzfeldt disease, investigations in cerebrospinal fluid and brain tissue showed disturbances of the monoamine metabolism. The levels of the eatecholamines were seriously decreased. Loading tests with probenecid suggested a low dopamine turnover. The lactate‐pyruvate ratio in CSF was normal. The histopathological findings are in good agreement with the biochemical data. The investigatio might possibly support the theory of a viral etiology in Jakob‐Creutzfeldt disease, and that a virus infection could be responsible for the impairment of the monoamine metabolism.