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BC 105 AND METHYSERGIDE (DESERIL®) IN MIGRAINE PROPHYLAXIS
Author(s) -
Presthus Jan
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07504.x
Subject(s) - methysergide , migraine , medicine , anesthesia , migraine disorders , significant difference , randomized controlled trial , antagonist , receptor
The value of BC 105 and methysergide in migraine prophylaxis has been compared in a double‐blind cross‐over trial with 19 patients. The sequence of the drugs has been randomized. No statistically significant difference in the effect of the two drugs could be shown in regard to the number of headache attacks, the intensity of pain, and the duration of headache attacks. Five patients felt most comfortable on BC 105 and seven on methysergide. When using BC 105 three patients complained initially of fatigue, and fourteen patients gained weight from 1.5–7.5 kg. The study indicates that the effect of BC 105 may be equal to methysergide in migraine prophylaxis.