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INTRACEREBRAL LESIONS CAUSING STEREOTYPED BEHAVIOUR IN RATS
Author(s) -
Fog Rasmus,
Pakkenberg Henning
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07502.x
Subject(s) - stereotypy , amphetamine , dopaminergic , reserpine , lesion , cholinergic , neuroscience , psychology , hippocampus , medicine , endocrinology , anesthesia , dopamine , psychiatry
Bilateral lesions performed with a microcannula in corpus spriatum, hippocampus or thalamus induce in reserpinized rats a stereotyped hyperactive behaviour for 6–8 min consisting of continuous biting without normal activities and resembling the amphetamine induced stereotypy. Bilateral cannula lesions of the dorsal cortex give a shorter response. The behavioural response is not influenced by inhibition of dopaminergic mechanisms in the brain and is prolonged by pretreatment with an anticholinergic drug. This lesion stereotypy is thus of neither dopaminergic nor cholinergic origin and, therefore, differs from the amphetamine stereotypy (dopaminergic) as well as the paradoxical reserpine stereotypy (cholinergic). Pretreatment with DOPA or a small dose of amphetamine as well as intracerebral injection of 25 % KCl or saline does not change the stereotypy.