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THE INFLUENCE OF BARBITURATE ANAESTHESIA UPON THE ENERGY STATE AND UPON ACID‐BASE PARAMETERS OF THE BRAIN IN ARTERIAL HYPOTENSION AND IN ASPHYXIA
Author(s) -
Nilsson Lorentz
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07479.x
Subject(s) - barbiturate , asphyxia , anesthesia , arterial blood , phosphocreatine , medicine , acidosis , chemistry , energy metabolism
The influence of barbiturate anaesthesia upon the energy and acid‐base metabolism of the brain was studied in arterial hypotension and in asphyxia by measuring the tissue concentrations of phosphocreatine, ATP, ADP, AMP, lactate, pyruvate, and bicarbonate. Intracellular lactate and pyruvate concentrations were derived after corrections for the lactate and pyruvate contained in the blood and extracellular fluid volumes of the tissue. Barbiturate anaesthesia was found to have a protective effect during arterial hypotension but not during total asphyxia.