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2‐(2.6‐DICHLOROPHENYLAMINO)‐2‐IMIDAZOLINE HYDROCHLORIDE (ST 155 OR CATAPRESAN) AS A PROPHYLACTIC REMEDY AGAINST MIGRAINE
Author(s) -
Sjaastad Ottar,
Stensrud Per
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07470.x
Subject(s) - lethargy , migraine , medicine , anesthesia , triptans , imidazoline receptor , hydrochloride , chemistry , organic chemistry
Twenty‐six migraine patients were included in a double blind study of the migraine‐reducing effect of 2‐(2.6‐dichlorophenylamino)‐2‐imidazoline hydrochloride (ST 155 or Catapresan). Sixteen of 26 patients (i.e. 62 per cent) experienced a reduction in headache indices when medicated with 75 μg of ST 155 daily (p < 0.025). The side effects of ST 155 in this dosage were trifling: a few patients complained of slight thirst, dryness of the mouth, or slight lethargy during the initial phase of drug therapy.