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ACTIVATION OF AMINO ACIDS IN THE BRAIN DURING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
Author(s) -
Wender M.,
Zgorzalewicz B.,
Wróblewski T.
Publication year - 1971
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1971.tb07463.x
Subject(s) - encephalomyelitis , amino acid , phenylalanine , white matter , brain tissue , asparagine , enzyme , central nervous system , biochemistry , chemistry , biology , medicine , immunology , magnetic resonance imaging , radiology
The activation of amino acids in the brain by sRNA synthetases was studied in experimental allergic encephalomyelitis. The results obtained lead to the following conclusions: (1) In the early period of the experimental disease (12 days after inoculation) in both the white and gray cerebral matter, a marked increase of the rate of activation of several amino acids was found. (2) Increased activities of sRNA synthetases, although insignificantly lower, were also observed in the preparalytical period of EAE before the appearance of any inflammatory signs in the brain. (3) During the paralytic period, only the activation rates of asparagine, glutamic acid, and phenylalanine were increased in the cerebral tissue. (4) The immunological reaction in EAE provoked alterations in the activity of the enzymatic system responsible for protein biosynthesis in the cerebral tissue.