Open AccessBDNF ‐mediated migration of cardiac microvascular endothelial cells is impaired during ageing
Author(s) -
Cao Liang,
Zhang Liang,
Chen Siyun,
Yuan Ziqiang,
Liu Shaokun,
Shen Xiaotao,
Zheng Xin,
Qi Xufeng,
Lee Kenneth K.H.,
Chan John YeukHon,
Cai Dongqing
Publication year - 2012
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2012.01621.x
Subject(s) - ageing , microbiology and biotechnology , neuroscience , chemistry , medicine , biology
This study indicates that brain‐derived neurotrophic factor ( BDNF ) can promote young cardiac microvascular endothelial cells ( CMEC s) to migrate via the activation of the BDNF ‐ TrkB ‐ FL ‐ PI 3K/Akt pathway, which may benefit angiogenesis after myocardial infarction ( MI ). However, the ageing of CMEC s led to changes in the expression of receptor Trk isoforms in that among the three isoforms ( TrkB ‐ FL , TrkB ‐ T 1 and TrkB ‐ T 2), only one of its truncated isoforms, TrkB ‐ T 1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMEC s and increased injury in ageing hearts. This shift in receptor isoforms in aged CMEC s, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.