Open AccessMurine spleen contains a diversity of myeloid and dendritic cells distinct in antigen presenting function
Author(s) -
Hey Ying Y.,
O'Neill Helen C.
Publication year - 2012
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2012.01608.x
Subject(s) - myeloid , antigen presentation , immune system , dendritic cell , antigen presenting cell , spleen , biology , antigen , immunology , acquired immune system , population , function (biology) , antigen processing , microbiology and biotechnology , t cell , medicine , environmental health
The spleen contains multiple subsets of myeloid and dendritic cells ( DC ). DC are important antigen presenting cells ( APC ) which induce and control the adaptive immune response. They are cells specialized for antigen capture, processing and presentation to naïve T cells. However, DC are a heterogeneous population and each subset differs subtly in phenotype, function and location. Similarly, myeloid cell subsets can be distinguished which can also play an important role in the regulation of immunity. This review aims to characterize splenic subsets of DC and myeloid cells to better understand their individual roles in the immune response.