Open AccessMicro RNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia
Author(s) -
Palma Catalina A.,
Tonna Elise J.,
Ma David F.,
Lutherborrow Mark A.
Publication year - 2012
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2011.01514.x
Subject(s) - myelopoiesis , microrna , haematopoiesis , biology , myeloid , progenitor cell , cellular differentiation , stem cell , cancer research , microbiology and biotechnology , immunology , genetics , gene
•Introduction •MicroRNA control of normal haematopoiesis ‐Haematopoietic stem cell (HSC) ‐Common myeloid progenitor (CMP) and initiation of myelopoiesis ‐Monocyte/macrophage differentiation ‐Granulocytic differentiation ‐Erythroid/megakaryocytic differentiation ‐MicroRNA control of malignant differentiation ‐MicroRNAs associated with abnormal monocytic differentiation ‐MicroRNAs associated with abnormal granulocytic differentiation ‐MicroRNAs associated with abnormal erythroid and megakaryocytic differentiation •Conclusion In the relatively short period of time since their discovery, micro RNA s have been shown to control many important cellular functions such as cell differentiation, growth, proliferation and apoptosis. In addition, micro RNA s have been demonstrated as key drivers of many malignancies and can function as either tumour suppressors or oncogenes. The haematopoietic system is not outside the realm of micro RNA control with micro RNA s controlling aspects of stem cell and progenitor self‐renewal and differentiation, with many, if not all, haematological disorders associated with aberrant micro RNA expression and function. In this review, we focus on the current understanding of micro RNA control of haematopoiesis and detail the evidence for the contribution and clinical relevance of aberrant micro RNA function to the characteristic block of differentiation in acute myeloid leukaemia.