Open AccessMicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
Author(s) -
Sana Jiri,
Hajduch Marian,
Michalek Jaroslav,
Vyzula Rostislav,
Slaby Ondrej
Publication year - 2011
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2011.01317.x
Subject(s) - microrna , biology , glioblastoma , angiogenesis , signal transduction , signalling pathways , regulation of gene expression , biological pathway , cancer research , gene expression , gene , computational biology , bioinformatics , microbiology and biotechnology , genetics
• Introduction • miRNAs signatures of glioblastoma tissue and cell lines • Involvement of miRNAs in core glioblastoma signalling pathways ‐ EGFR and PI3K/AKT signalling pathways ‐ p53, TGF‐β and apoptotic signalling pathways ‐ IFN‐α/IFN‐β signalling pathways ‐ Notch signalling pathway ‐ NF‐κB signalling pathway• Single nucleotide polymorphisms and miRNAs: risk factors for glioblastoma • miRNAs in glioblastoma prognosis and prediction of therapeutic response • miRNAs involved in drug resistance of glioblastoma • miRNAs as potential therapeutic targets • ConclusionsMicroRNAs (miRNAs) are endogenously expressed small non‐coding RNAs that act as post‐transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.