Open AccessDoes autophagy take a front seat in lifespan extension?
Author(s) -
Petrovski Goran,
Das Dipak K.
Publication year - 2010
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2010.01196.x
Subject(s) - autophagy , ageing , pi3k/akt/mtor pathway , microbiology and biotechnology , ampk , calorie restriction , lipofuscin , biology , mtorc1 , apoptosis , signal transduction , biochemistry , endocrinology , protein kinase a , kinase , genetics
• Introduction• Signalling cascades regulating the ageing process• Ageing and autophagy‐ Lipofuscin and the mitochondrial‐lysosomal axis theory of aging• Signalling cascades regulating autophagy• Pharmacological manipulations to induce autophagy• Future perspectivesThis review focuses on the interrelationship between ageing and autophagy. There is a striking similarity between the signalling aspects of these two processes. Both ageing and autophagy involve several of the signalling components such as insulin/IGF‐1, AMPK, Ras‐cAMP‐PKA, Sch9 and mTOR. Ageing and ageing‐mediated defective autophagy involve accumulation of lipofuscin. Components of anti‐ageing and autophagy include SirTs and FoxOs. Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan. Such striking similarities indicate that lifespan is strongly dependent on autophagy.