Open AccessEngineering skeletal muscle tissue – new perspectives in vitro and in vivo
Author(s) -
Klumpp Dorothee,
Horch Raymund E.,
Kneser Ulrich,
Beier Justus P.
Publication year - 2010
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2010.01183.x
Subject(s) - skeletal muscle , duchenne muscular dystrophy , myocyte , muscular dystrophy , tissue engineering , muscle tissue , in vivo , in vitro , medicine , microbiology and biotechnology , biology , biomedical engineering , anatomy , biochemistry
• Introduction• Matrices for skeletal muscle tissue engineering – gaining orientation• Electrospun nanofibre matrices• Nanotechnology and smart matrices• Cell sources for skeletal muscle TE• ConclusionMuscle tissue engineering (TE) has not yet been clinically applied because of several problems. However, the field of skeletal muscle TE has been developing tremendously and new approaches and techniques have emerged. This review will highlight recent developments in the field of nanotechnology, especially electrospun nanofibre matrices, as well as potential cell sources for muscle TE. Important developments in cardiac muscle TE and clinical studies on Duchenne muscular dystrophy (DMD) will be included to show their implications on skeletal muscle TE.